Why study the genetic factors influencing the age at natural menopause?
نویسندگان
چکیده
Moron et al.: Genome Medicine 2009, 1:76 Abstract The age at natural menopause shows great variability. It has been proposed that early age at menopause is a risk factor for osteoporosis and cardiovascular disease, whereas later age at menopause is a risk factor for breast cancer. In addition, it is thought that the genetic factors accounting for the genetic variability in age at menopause could also play a role in those diseases, as well as infertility in women. In this minireview we comment on the latest genetics and genomics insights into age at natural menopause.
منابع مشابه
سن یائسگی طبیعی و عوامل اجتماعی - جمعیتی در شیراز 1379
Ôbjective : The relation of the mean age at natural menopause with socio-demographic factors was calculated among women in Shiraz. The data were obtained from a population-based cross sectional study carried out in the year 2000. Materials and methods: Ïnterviews were carried out and observation made on 948 women who had undergone a natural menopause, chosen randomly using postal zones hou...
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Background To investigate the role of the anti-Müllerian hormone (AMH) signalling pathway in the pathophysiology of idiopathic primary ovarian insufficiency (POI) and age at natural menopause (ANM) using a genetic approach MaterialsAndMethods DNA sequencing was used to detect the genotype distribution and allele frequency of the genes AMH and AMH receptor II (AMHR2) in 120 cases of idiopathic P...
متن کاملDeterminants of Age at Natural Menopause in Shiraz
The mean age at natural menopause and its determinants among Shirazi women (southern Iran) was calculated. The data were obtained from a population- based cross-sectional study carried out in the year 2000. Interviews were carried out and observations made on 948 women who had incurred natural menopause. They were randomly chosen using postal zones housing sample framework of Shiraz.Mean±SD a...
متن کاملبررسی ارتباط برخی عوامل اقتصادی- اجتماعی با یائسگی در مراجعین به مراکز بهداشتی درمانی شهر همدان
Background: Menopause is an important event in women's life. So it is really important for them to be healthy in this stage. The purpose of this study was to determine the socio-economical factors related to age at menopause in Hamadan city. Methods: This cross-sectional study was carried out on 400 menopausal women among 40-65 years old who were selected randomly from 5 health centers in Hame...
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Abstract Background: Various studies have shown the age changes of menopause in Iran, in a relatively wide area, approximately from 46 to 51 years. This broad range of the changes can attribute not only to the essential difference between women of different regions, but could also be related to methodological problems. Because the model of menopause age could be estimated by cohort or a cros...
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تاریخ انتشار 2009